MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism
J Huo, JD Molkentin - Trends in Endocrinology & Metabolism, 2024 - cell.com
Skeletal muscle has a major impact on total body metabolism and obesity, and is
characterized by dynamic regulation of substrate utilization. While it is accepted that acute …
characterized by dynamic regulation of substrate utilization. While it is accepted that acute …
[HTML][HTML] Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses
G Anderson - Exploration of targeted anti-tumor therapy, 2023 - ncbi.nlm.nih.gov
A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …
Enhanced presynaptic mitochondrial energy production is required for memory formation
Some of the prominent features of long-term memory formation include protein synthesis,
gene expression, enhanced neurotransmitter release, increased excitability, and formation …
gene expression, enhanced neurotransmitter release, increased excitability, and formation …
MICU1's calcium sensing beyond mitochondrial calcium uptake
SD Kaye, S Goyani, D Tomar - … et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
The discovery of MICU1 as gatekeeper of mitochondrial calcium (m Ca 2+) entry has
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …
MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart
P Hasan, E Berezhnaya, M Rodríguez-Prados… - Proceedings of the …, 2024 - pnas.org
Activating Ca2+-sensitive enzymes of oxidative metabolism while preventing calcium
overload that leads to mitochondrial and cellular injury requires dynamic control of …
overload that leads to mitochondrial and cellular injury requires dynamic control of …
The lysosomal calcium channel TRPML1 maintains mitochondrial fitness in NK cells through interorganelle cross-talk
D Clement, EK Szabo, SZ Krokeide… - The Journal of …, 2023 - journals.aai.org
Cytotoxic lymphocytes eliminate cancer cells through the release of lytic granules, a
specialized form of secretory lysosomes. This compartment is part of the pleomorphic …
specialized form of secretory lysosomes. This compartment is part of the pleomorphic …
Structural analysis of mitochondria in cardiomyocytes: insights into bioenergetics and membrane remodeling
RA Adams, Z Liu, C Hsieh, M Marko… - Current Issues in …, 2023 - mdpi.com
Mitochondria in mammalian cardiomyocytes display considerable structural heterogeneity,
the significance of which is not currently understood. We use electron microscopic …
the significance of which is not currently understood. We use electron microscopic …
MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy
BACKGROUND: Calcium (Ca2+) uptake by mitochondria occurs via the mitochondrial Ca2+
uniporter. Mitochondrial Ca2+ uniporter exists as a complex, regulated by 3 MICU …
uniporter. Mitochondrial Ca2+ uniporter exists as a complex, regulated by 3 MICU …
Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease
TL Stevens, HM Cohen, JF Garbincius… - Nature Cardiovascular …, 2024 - nature.com
Abstract The mitochondrial calcium (mCa2+) uniporter channel (mtCU) resides at the inner
mitochondrial membrane and is required for Ca2+ to enter the mitochondrial matrix. The …
mitochondrial membrane and is required for Ca2+ to enter the mitochondrial matrix. The …
Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy
The complex architecture and biochemistry of the inner mitochondrial membrane generate
ultra-structures with different phospholipid and protein compositions, shapes, characteristics …
ultra-structures with different phospholipid and protein compositions, shapes, characteristics …