Skeletal muscle has a major impact on total body metabolism and obesity, and is
characterized by dynamic regulation of substrate utilization. While it is accepted that acute …

A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …

Some of the prominent features of long-term memory formation include protein synthesis,
gene expression, enhanced neurotransmitter release, increased excitability, and formation …

The discovery of MICU1 as gatekeeper of mitochondrial calcium (m Ca 2+) entry has
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …

Activating Ca2+-sensitive enzymes of oxidative metabolism while preventing calcium
overload that leads to mitochondrial and cellular injury requires dynamic control of …

Cytotoxic lymphocytes eliminate cancer cells through the release of lytic granules, a
specialized form of secretory lysosomes. This compartment is part of the pleomorphic …

Mitochondria in mammalian cardiomyocytes display considerable structural heterogeneity,
the significance of which is not currently understood. We use electron microscopic …

BACKGROUND: Calcium (Ca2+) uptake by mitochondria occurs via the mitochondrial Ca2+
uniporter. Mitochondrial Ca2+ uniporter exists as a complex, regulated by 3 MICU …

Abstract The mitochondrial calcium (mCa2+) uniporter channel (mtCU) resides at the inner
mitochondrial membrane and is required for Ca2+ to enter the mitochondrial matrix. The …

The complex architecture and biochemistry of the inner mitochondrial membrane generate
ultra-structures with different phospholipid and protein compositions, shapes, characteristics …