Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …

Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

Mutational activation of KRAS promotes the initiation and progression of cancers, especially
in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific …

The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify
AMER1 as a key regulator of ferroptosis. AMER1 loss causes resistance to ferroptosis in …

Background & Aims The hepatocyte Notch pathway is a pathogenic factor in non-alcoholic
steatohepatitis (NASH)-associated fibrosis, but its role in hepatocellular carcinoma (HCC) is …

AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin
signaling pathway, and subsequently unveiled its integral involvement across a diverse …

Increased expression of the kinesin family member 23 (KIF23) has been verified in gastric
cancer (GC) and its upregulation contributes to cell proliferation. Even though, the role of …

Purpose: Somatic mutations occur at early stages of adenoma and accumulate throughout
colorectal cancer progression. The aim of this study was to characterize the mutational …

Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin
signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed …

Endosseous implants are important tools to replace missing teeth or damaged tissue
segments. Their clinical success depends on their integration in bone and, thus, on the …