Knowledge on the genetic basis of Parkinson's disease has grown tremendously since the
discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the …

α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In
Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …

Reversible protein phosphorylation, regulated by protein phosphatases, fine-tunes target
protein function and plays a vital role in biological processes. Dysregulation of this process …

A series of novel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise
selective, potent modulators of the protein–protein interaction (PPI)-mediated functions of …

Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body
cleaving proline-containing peptides; however, recent studies suggest that its effects on …

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2
shows promise for tumor diagnosis, prognosis, and treatment. This study explored …

ABSTRACT Background and Objective Early‐onset Parkinson's disease (EOPD) commonly
recognizes a genetic basis; thus, patients with EOPD are often addressed to diagnostic …

As the global population ages, the incidence of Parkinson's Disease (PD) continues to rise,
imposing significant social and economic burdens. Mangiferin (MGF), a polyphenolic …

Abstract α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking.
In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …

We read with great interest the recent article by Fevga and colleagues 1 delineating the role
of bi-allelic variants in the PTPA gene (OMIM* 600756) and their association with autosomal …