Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

Background Pain remains a prevalent symptom for rheumatoid arthritis (RA) patients despite
a wide therapeutic choice. The objective of this study was to provide a multidimensional …

Objective Cantleyoside (CA) is a kind of iridoid glycosides in Pterocephalus hookeri (CB
Clarke) Höeck. The purpose of this study was to investigate the effects of CA on human …

Background Rheumatoid arthritis (RA) can cause severe physical impairment and a reduced
quality of life, and there is limited evidence for any effective intervention. Aerobic exercise …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by
macrophage activation. The current characteristics, hotspots, and research frontiers of …

The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway has recently emerged
as a novel therapeutic target in treating various diseases. Therefore, the present study …

Intestinal bacterial compositions of rheumatoid arthritis (RA) patients have been reported to
be different from those of healthy people. Dysbiosis, imbalance of the microbiota, is widely …

The major therapeutic challenge in inflammatory rheumatic diseases is the persistence of
pain despite good responses to specific therapies. Central sensitization, which can be …