Translational regulation by uORFs and start codon selection stringency
In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …
Non-AUG translation initiation in mammals
DE Andreev, G Loughran, AD Fedorova… - Genome Biology, 2022 - Springer
Recent proteogenomic studies revealed extensive translation outside of annotated protein
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …
Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions
NE Shirokikh, T Preiss - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …
decode the messenger RNA template by cycling through translation initiation, elongation …
Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
IP Ivanov, JA Saba, CM Fan, J Wang… - Proceedings of the …, 2022 - National Acad Sciences
Translation start site selection in eukaryotes is influenced by context nucleotides flanking the
AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a …
AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a …
Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of
Met-tRNAi in a 'PIN'state, which is antagonized by the factor eIF1. eIF5 is a GTPase …
Met-tRNAi in a 'PIN'state, which is antagonized by the factor eIF1. eIF5 is a GTPase …
Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding
T Havkin-Solomon, E Itzhaki, N Joffe… - Nucleic acids …, 2023 - academic.oup.com
RPS3, a universal core component of the 40S ribosomal subunit, interacts with mRNA at the
entry channel. Whether RPS3 mRNA-binding contributes to specific mRNA translation and …
entry channel. Whether RPS3 mRNA-binding contributes to specific mRNA translation and …
DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation
A CGG trinucleotide repeat expansion in the 5′ UTR of FMR 1 causes the
neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This …
neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This …
[HTML][HTML] Aberrant protein synthesis and cancer development: The role of canonical eukaryotic initiation, elongation and termination factors in tumorigenesis
In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …
[HTML][HTML] Suppression of ribosomal pausing by eIF5A is necessary to maintain the fidelity of start codon selection
Sequences within 5′ UTRs dictate the site and efficiency of translation initiation. In this
study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the …
study, an unbiased screen designed to interrogate the 5′ UTR-mediated regulation of the …
Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story
ED Shestakova, VV Smirnova, IN Shatsky, IM Terenin - Rna, 2023 - rnajournal.cshlp.org
The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …