Viral replication is a process that involves an extremely high turnover of cellular molecules.
Since viruses depend on the host cell to obtain the macromolecules needed for their proper …

Cellular phospholipids (PLs) differ by the nature of their polar heads as well as by the length
and unsaturation level of their fatty acyl chains. We discuss how the ratio between saturated …

The metabolic oxidative degradation of cellular lipids severely restricts replication of
hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the …

The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …

Membrane association is a hallmark of the genome replication of positive-strand RNA
viruses [(+) RNA viruses]. All well-studied (+) RNA viruses remodel host membranes and …

Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This
includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes …

Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV
infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Motivation: Lipids are a large and diverse group of biological molecules with roles in
membrane formation, energy storage and signaling. Cellular lipidomes may contain tens of …

The circadian clock regulates immune responses to microbes and affects pathogen
replication, but the underlying molecular mechanisms are not well understood. Here we …