Background There is a critical need to better understand the mechanisms that drive local cell
invasion and metastasis to develop new therapeutics targeting metastatic disease …

Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP
production. We have previously reported that cancer cells import extracellular citrate via the …

Although membrane potentials (Vms) are fundamental to the functioning broadly of all cell
types, Vm dynamics have mostly been studied in the so-called “excitable” cells (mainly …

The defining principle of evolutionary biology is that all species, extant and extinct, evolved
from ancient prokaryotic cells. Their initial appearance and adaptive evolution are proposed …

Giant plasma membrane vesicles (GPMVs) have been utilized as a model to study phase
separation in the plasma membrane. Additionally, GPMVs have been employed as vehicle …

Fluxes of monovalent ions through the multiple pathways of the plasma membrane are
highly interdependent, and their assessment by direct measurement is difficult or even …

Background During embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R)
breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased …

Plasma membrane segregation into various nanoscale membrane domains is driven by
distinct interactions between diverse lipids and proteins. Among them, liquid-ordered (L o) …

Background Monoclonal antibodies (mABs) have emerged as one of the most important
therapeutic recombinant proteins in the pharmaceutical industry. Their immunogenicity and …

Bioelectric signals possess the ability to robustly control and manipulate patterning during
embryogenesis and tissue-level regeneration. Endogenous local and global electric fields …