[HTML][HTML] The Multifaceted Role of Cofilin in Neurodegeneration and Stroke: Insights into Pathogenesis and Targeting as a Therapy

F Shehjar, DA Almarghalani, R Mahajan, SAM Hasan… - Cells, 2024 - mdpi.com
This comprehensive review explores the complex role of cofilin, an actin-binding protein,
across various neurodegenerative diseases (Alzheimer's, Parkinson's, schizophrenia …

Update on the mechanism of microglia involvement in post-stroke cognitive impairment

T Zeng, J Liu, W Zhang, Y Yu, X Ye, Q Huang… - Frontiers in Aging …, 2024 - frontiersin.org
Post-stroke cognitive impairment (PSCI) is a clinical syndrome characterized by cognitive
deficits that manifest following a stroke and persist for up to 6 months post-event. This …

Neural Stem Cell-Derived Exosomes Improve Neurological Function in Rats with Cerebral Ischemia-Reperfusion Injury by Regulating Microglia-Mediated …

X Zhao, J Zhu, S Chen, R Liu, T Long - Journal of Inflammation …, 2023 - Taylor & Francis
Purpose To investigate the effect of neural stem cell-derived exosomes (NSC-Exos) on
neural function after rat cerebral ischemia-reperfusion injury by regulating microglia …

[HTML][HTML] G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different …

GDB Machado, AL Schnitzler, AW Fleischer… - Hormones and …, 2024 - Elsevier
Studies in ovariectomized (OVX) female rodents suggest that G protein-coupled estrogen
receptor (GPER) is a key regulator of memory, yet little is known about its importance to …

Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related …

DA Almarghalani, GA Bahader, M Ali… - Pharmaceuticals, 2024 - mdpi.com
Neuroinflammation after intracerebral hemorrhage (ICH) is a crucial factor that determines
the extent of the injury. Cofilin is a cytoskeleton-associated protein that drives …

[HTML][HTML] Hyperchloremia and Hypernatremia Decreased Microglial and Neuronal Survival during Oxygen–Glucose Deprivation/Reperfusion

R Mahajan, F Shehjar, AI Qureshi, ZA Shah - Biomedicines, 2024 - mdpi.com
Hyperchloremia and hypernatremia are associated with higher mortality in ischemic stroke,
but it remains unclear whether their influence directly contributes to ischemic injury. We …

Investigation of the Role of the G-Protein-Coupled Estrogen Receptor in Memory Consolidation in Gonadectomized Male Mice

GDB Machado - 2023 - search.proquest.com
Estrogens are cholesterol-derived hormones that play crucial physiological and pathological
roles in both sexes and across the lifespan. Many research groups have replicated the …