Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis
Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …
[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
APD: the antimicrobial peptide database
Z Wang, G Wang - Nucleic acids research, 2004 - academic.oup.com
An antimicrobial peptide database (APD) has been established based on an extensive
literature search. It contains detailed information for 525 peptides (498 antibacterial, 155 …
literature search. It contains detailed information for 525 peptides (498 antibacterial, 155 …
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
X Li, Y Li, H Han, DW Miller… - Journal of the American …, 2006 - ACS Publications
To understand the structure and activity relationship of human LL-37, a series of peptide
fragments was designed. The N-terminal fragment, LL-37 (1− 12), was not active, while the …
fragments was designed. The N-terminal fragment, LL-37 (1− 12), was not active, while the …
Peptide‐based approaches to fight biofouling
GP Sakala, M Reches - Advanced Materials Interfaces, 2018 - Wiley Online Library
Biofouling is the undesirable accumulation of organisms such as bacteria, fungi, and
barnacles on surfaces. It is a serious problem in many areas of our lives including health …
barnacles on surfaces. It is a serious problem in many areas of our lives including health …
Structural models of human apolipoprotein AI: a critical analysis and review
CG Brouillette, GM Anantharamaiah, JA Engler… - … et Biophysica Acta (BBA …, 2001 - Elsevier
Human apolipoprotein (apo) AI has been the subject of intense investigation because of its
well-documented anti-atherogenic properties. About 70% of the protein found in high density …
well-documented anti-atherogenic properties. About 70% of the protein found in high density …
Prediction of antimicrobial peptides based on sequence alignment and feature selection methods
Antimicrobial peptides (AMPs) represent a class of natural peptides that form a part of the
innate immune system, and this kind of 'nature's antibiotics' is quite promising for solving the …
innate immune system, and this kind of 'nature's antibiotics' is quite promising for solving the …
Extracting information from the temperature gradients of polypeptide NH chemical shifts. 1. The importance of conformational averaging
NH Andersen, JW Neidigh, SM Harris… - Journal of the …, 1997 - ACS Publications
A detailed analysis of backbone amide NH chemical shift temperature gradients (Δδ/Δ T
values) for proteins and highly cross-linked peptides reveals that hydrogen-bonded …
values) for proteins and highly cross-linked peptides reveals that hydrogen-bonded …
Design and surface immobilization of short anti-biofilm peptides
Short antimicrobial peptides are essential to keep us healthy and their lasting potency can
inspire the design of new types of antibiotics. This study reports the design of a family of …
inspire the design of new types of antibiotics. This study reports the design of a family of …
Inter-molecular coiled-coil formation in human apolipoprotein E C-terminal domain
N Choy, V Raussens, V Narayanaswami - Journal of molecular biology, 2003 - Elsevier
Human apolipoprotein E (apoE) is composed of an N-terminal (NT) domain (residues 1–
191) that bears low-density lipoprotein receptor-binding sites, and a C-terminal (CT) domain …
191) that bears low-density lipoprotein receptor-binding sites, and a C-terminal (CT) domain …