[HTML][HTML] Novel factors regulating proliferation, migration, and differentiation of fibroblasts, keratinocytes, and vascular smooth muscle cells during wound healing

J Smith, V Rai - Biomedicines, 2024 - pmc.ncbi.nlm.nih.gov
Chronic diabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus, often
leading to amputation, increased morbidity, and a substantial financial burden. Even with the …

E-cadherin re-expression: its potential in combating TRAIL resistance and reversing epithelial-to-mesenchymal transition

SH San, SC Ngai - Gene, 2024 - Elsevier
The major limitation of conventional chemotherapy drugs is their lack of specificity for cancer
cells. As a selective apoptosis-inducing agent, tumor necrosis factor (TNF)-related apoptosis …

Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC

S Huang, J Hu, M Hu, Y Hou, B Zhang, J Liu, X Liu… - Oncogene, 2024 - nature.com
High invasive capacity and acquired tyrosine kinase inhibitors (TKI) resistance of kidney
renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of …

SIX1 amplification modulates stemness and tumorigenesis in breast cancer

L Guo, F Li, H Liu, D Kong, C Chen, S Sun - Journal of Translational …, 2023 - Springer
Background Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has
recently been identified as a crucial regulator of embryonic development and tumorigenesis …

miR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion

X Liu, H Cui, Q Bai, H Piao, Y Song, G Yan - International …, 2024 - Elsevier
Bronchial asthma is known for airway inflammation, hyperresponsiveness, and remodeling.
MicroRNAs (MiRNAs) have been involved in the development of asthma, whereas, the …

Implications of ITCH-mediated ubiquitination of SIX1 on CDC27-cyclinB1 signaling in nasopharyngeal carcinoma

Z Lin, W Cai, Y Sun, B Han, Y Hu, S Huang, J Li… - Scientific Reports, 2024 - nature.com
Nasopharyngeal carcinoma (NPC) presents a significant medical challenge due to its high
incidence rate and poor prognosis, which are attributed primarily to tumor metastasis and …

SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy

A Fox, J Oliva, R Vangipurapu, FM Sverdrup - Skeletal Muscle, 2024 - Springer
Facioscapulohumeral muscular dystrophy (FSHD) is a common and progressive muscle
wasting disease that is characterized by muscle weakness often first noticed in the face, the …

Transcriptomic Changes Following Induced De-Masculinisation of Australian Red Claw Crayfish Cherax quadricarinatus

G Smith, S Glendinning, T Ventura - International Journal of Molecular …, 2023 - mdpi.com
The Australian red claw crayfish Cherax quadricarinatus, an emerging species within the
freshwater aquaculture trade, is not only an ideal species for commercial production due to …

SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration

Z Shao, S Liu, W Sun, X Zhuang, S Yin, J Cheng… - Cellular & Molecular …, 2024 - Springer
Sentrin/SUMO-specific protease 3 (SENP3) is essential to regulate protein stability and
function in normal and cancer cells. Nevertheless, its role and action mechanisms in …

BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation

P Zhang, W Zhang, X Wang, L Li, Y Lin, N Wu, R Mao… - Cancer Letters, 2024 - Elsevier
Esophageal cancer ranks among the most prevalent malignant tumors, and esophageal
squamous cell carcinoma (ESCC) constitutes its predominant histological form. Despite its …