Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …
and influence cellular function via effects on membrane properties, and also by acting as a …
Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
Specialized pro-resolving mediators as resolution pharmacology for the control of pain and itch
RR Ji - Annual review of pharmacology and toxicology, 2023 - annualreviews.org
Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins,
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …
Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration
This review is a synopsis of the main points from the opening presentation by the authors in
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …
Inflammation and Infection in Pain and the Role of GPR37
Inflammation is known to cause pain, and pain is of one of the cardinal signs of
inflammation. Mounting evidence suggests that acute inflammation also resolves pain …
inflammation. Mounting evidence suggests that acute inflammation also resolves pain …
M2 macrophage polarization: A potential target in pain relief
W Zhao, L Ma, D Deng, T Zhang, L Han, F Xu… - Frontiers in …, 2023 - frontiersin.org
Pain imposes a significant urden on patients, affecting them physically, psychologically, and
economically. Despite numerous studies on the pathogenesis of pain, its clinical …
economically. Despite numerous studies on the pathogenesis of pain, its clinical …
[HTML][HTML] Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to
facilitate intercellular communication and promote the resolution of inflammation. However …
facilitate intercellular communication and promote the resolution of inflammation. However …
The programmed cell death of macrophages, endothelial cells, and tubular epithelial cells in sepsis-AKI
C Li, W Wang, S Xie, W Ma, Q Fan, Y Chen, Y He… - Frontiers in …, 2021 - frontiersin.org
Sepsis is a systemic inflammatory response syndrome caused by infection, following with
acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently …
acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently …
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis
G protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown
functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed …
functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed …
Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission
Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central
nervous system and requires low chloride concentration in neurons, maintained by KCC2, a …
nervous system and requires low chloride concentration in neurons, maintained by KCC2, a …