Coenzyme Q (Q) is a key component for bioenergetics and antioxidant protection in the cell.
During the last years, research on diseases linked to Q-deficiency has highlighted the …

Ageing is accompanied by the accumulation of damaged molecules in cells due to the injury
produced by external and internal stressors. Among them, reactive oxygen species …

Aging, a major risk factor in Alzheimer's disease (AD), is associated with an oxidative redox
shift, decreased redox buffer protection, and increased free radical reactive oxygen species …

Significance: The vasculature responds to the respiratory needs of tissue by modulating
luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion …

Oocyte quality is the limiting factor in female fertility. It is well known that maternal nutrition
plays a role in reproductive function, and manipulating nutrition to improve fertility in …

Age-related alteration of mitochondria causes impaired cardiac function, along with cellular
and molecular changes. Polyamines can extend life span in mice. However, whether …

Coenzyme Q (CoQ) is a key component for many essential metabolic and antioxidant
activities in cells in mitochondria and cell membranes. Mitochondrial dysfunction is one of …

Among mitochondrial NADP‐reducing enzymes, nicotinamide nucleotide transhydrogenase
(NNT) establishes an elevated matrix NADPH/NADP+ by catalyzing the reduction of NADP+ …

Abstract Aims: Membrane-bound CYB5R3 deficiency in humans causes recessive
hereditary methaemoglobinaemia (RHM), an incurable disease that is characterized by …

Although great effort has been expended to understand cancer's origins, less attention has
been given to the primary cause of cancer deaths—cancer recurrences and their sequelae …