[HTML][HTML] Regulation of hepatic innate immunity by hepatitis C virus

SM Horner, M Gale Jr - Nature medicine, 2013 - nature.com
Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
liver, which can cause liver disease and is linked with liver cancer. Viral innate immune …

IL28BGenomic-Based Treatment Paradigms for Patients with Chronic Hepatitis C Infection: The Future of Personalized HCV Therapies

PJ Clark, AJ Thompson… - Official journal of the …, 2011 - journals.lww.com
Genome-wide association studies (GWAS) have recently identified host genetic variation to
be critical for predicting treatment response and spontaneous clearance in patients infected …

[PDF][PDF] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon …

N Akuta, F Suzuki, M Hirakawa, Y Kawamura… - …, 2010 - Wiley Online Library
Genetic variation near the IL28B gene and substitution of amino acid (aa) 70 and 91 in the
core region of hepatitis C virus (HCV) genotype 1b can predict the response to pegylated …

[PDF][PDF] Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop

RT Chung, M Gale Jr, SJ Polyak, SM Lemon… - …, 2008 - Wiley Online Library
The current recommended therapy for chronic hepatitis C is the combination of peginterferon
and ribavirin, which results in a sustained clearance of hepatitis C virus (HCV) in at least half …

Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans

R Aurora, MJ Donlin, NA Cannon… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Hepatitis C virus (HCV) is a common RNA virus that causes hepatitis and liver cancer.
Infection is treated with IFN-α and ribavirin, but this expensive and physically demanding …

[HTML][HTML] Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview

A El-Shamy, H Hotta - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. HCV is able to evade
host defense mechanisms, including both innate and acquired immune responses, to …

Evidence for separation of HCV subtype 1a into two distinct clades

BE Pickett, R Striker, EJ Lefkowitz - Journal of viral hepatitis, 2011 - Wiley Online Library
The nucleotide sequence diversity present among hepatitis C virus (HCV) isolates allows
rapid adjustment to exterior forces including host immunity and drug therapy. This viral …

Mutations in the Hepatitis C Virus core Gene Are Associated with Advanced Liver Disease and Hepatocellular Carcinoma

SL Fishman, SH Factor, C Balestrieri, X Fan… - Clinical Cancer …, 2009 - AACR
Abstract Purpose: Hepatitis C virus (HCV) infection can promote the development of
hepatocellular carcinoma (HCC). Published data implicate the HCV core gene in …

[PDF][PDF] Natural killer inhibitory receptor expression associated with treatment failure and interleukin‐28B genotype in patients with chronic hepatitis C

L Golden‐Mason, KM Bambha, L Cheng… - …, 2011 - Wiley Online Library
Natural killer (NK) cells constitute a first line of defense against viral infections; their function
is governed by the integration of signals from multiple activating and inhibitory surface …

BK polyomavirus diversity—why viral variation matters

JT Blackard, SM Davies… - Reviews in medical …, 2020 - Wiley Online Library
BK polyomavirus (BKPyV or BKV) is a non‐enveloped, circular double‐stranded DNA virus
that may exceed 80% seroprevalence in adults. BKV infection typically occurs during …