The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair
and is associated with an increased risk of cancer,–. However, how such cycles affect the …

The gastrointestinal tract houses millions of microbes, and thus has evolved several host
defense mechanisms to keep them at bay, and prevent their entry into the host. One such …

Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD), which is
characterized by diffuse inflammation of the mucosa of the colon and rectum. Abdominal …

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD)
characterized by intestinal inflammation. Increased intestinal levels of the proinflammatory …

A20, also known as TNFAIP3, is a potent regulator of ubiquitin (Ub) dependent signals. A20
prevents multiple human diseases, indicating that the critical functions of this protein are …

Evodiamine (Evo) is an alkaloid that can be extracted from the berry fruit Evodia rutaecarpa
and has been reported to exert various pharmacological effects, such as antidiarrheal …