Cognitive symptoms are common, and yet many who seek help for cognitive symptoms
neither have, nor go on to develop, dementia. A proportion of these people are likely to have …

Executive dysfunction can be present from the early stages of P arkinson's disease (PD). It is
characterized by deficits in internal control of attention, set shifting, planning, inhibitory …

The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses
recognition memory. Recognition memory is disturbed in a range of human disorders and …

Optical coherence tomography is a simple, high-resolution technique to quantify the
thickness of retinal nerve fiber layer (RNFL). Previous studies have shown that degenerative …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet
disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) …

Background and purpose Studies of high body mass index (BMI) and cognition in the elderly
have shown conflicting results. While some studies have shown a detrimental effect of high …

Neuroimaging findings suggest that older people may be more aware of underlying brain
changes than was previously apparent or than can be detected using conventional …

The administration of reserpine to rodents was one of the first models used to investigate the
pathophysiology and screening for potential treatments of P arkinson's disease (PD). The …

Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's
disease (PD). However, in general, classic animal models are based on severe motor …

Cognitive symptoms of Parkinson's disease (PD) have been long underestimated, but are
some of the most disabling non-motor features of the disease. In order to establish signs that …