In-depth characterization of full-length archived viral genomes after nine years of posttreatment HIV control

P Trémeaux, F Lemoine, A Mélard… - Microbiology …, 2023 - Am Soc Microbiol
In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without
antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission. To …

Single-particle discrimination of retroviruses from extracellular vesicles by nanoscale flow cytometry

VA Tang, TM Renner, AK Fritzsche, D Burger… - Scientific reports, 2017 - nature.com
Retroviruses and small EVs overlap in size, buoyant densities, refractive indices and share
many cell-derived surface markers making them virtually indistinguishable by standard …

Full-length glycosylated Gag of murine leukemia virus can associate with the viral envelope as a type I integral membrane protein

TM Renner, K Bélanger, C Lam, MCR Gerpe… - Journal of …, 2018 - Am Soc Microbiol
The glycosylated Gag protein (gPr80) of murine leukemia viruses (MLVs) has been shown to
exhibit multiple roles in facilitating retrovirus release, infection, and resistance to host …

N-Linked Glycosylation Protects Gammaretroviruses against Deamination by APOBEC3 Proteins

MC Rosales Gerpe, TM Renner, K Bélanger… - Journal of …, 2015 - Am Soc Microbiol
Retroviruses are pathogens with rapid infection cycles that can be a source of disease,
genome instability, and tumor development in their hosts. Host intrinsic restriction factors …

On the nucleotide composition and structure of retroviral RNA genomes

F van Hemert, AC van der Kuyl, B Berkhout - Virus research, 2014 - Elsevier
Retroviral RNA genomes display a rich variety in their nucleotide composition. For instance,
the single-stranded RNA genome of human T cell leukemia virus (HTLV-1) is C-rich and G …

[HTML][HTML] RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency

K Bélanger, MA Langlois - Virology, 2015 - Elsevier
Abstract APOBEC3G (A3G) is a host-expressed protein that inactivates retroviruses through
the mutagenic deamination of cytosines (C) to uracils (U) in single-stranded DNA (ssDNA) …

Species identification using high resolution melting (HRM) analysis with random forest classification

S Bowman, D McNevin, SJ Venables… - Australian Journal of …, 2019 - Taylor & Francis
Species identification is an important facet of forensic investigation. In this study, human and
non-human species (cow, chicken, pig, sheep, cat, dog, rabbit, fox, kangaroo and wombat) …

Comparative analysis of the gene-inactivating potential of retroviral restriction factors APOBEC3F and APOBEC3G

K Belanger, MA Langlois - Journal of General Virology, 2015 - microbiologyresearch.org
APOBEC3 (A3) proteins are host-encoded restriction factors that inhibit retrovirus infection
by mutagenic deamination of cytosines in minus-strand DNA replication intermediates …

The Role of APOBEC3 in Controlling Retroviral Spread and Zoonoses

MC Rosales Gerpe - 2014 - ruor.uottawa.ca
APOBEC3 (A3) proteins are a family of host-encoded cytidine deaminases that protect
against retroviruses and other viral intruders. Retroviruses, unlike other viruses, are able to …

Effects of APOBEC3-Induced Mutations on HIV-1 Expression and Latency

C Lam - 2019 - ruor.uottawa.ca
One of the greatest barriers to curing HIV-1 is the ability of the virus to establish a state of
latent infection within infected cells. During viral latency, the virus lies dormant in the form of …