During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

There is a growing awareness that gut commensal metabolites play a major role in host
physiology and indeed the pathophysiology of several illnesses. The composition of the …

Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature
of a major subset of primary human brain cancers. These mutations occur at a single amino …

Clinical observations suggest that gut and dietary factors transiently worsen and, in some
cases, appear to improve behavioral symptoms in a subset of persons with autism spectrum …

Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of
essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the …

Recent evidence suggests that a variety of environmental factors, including dietary and
gastrointestinal agents, may contribute to autism spectrum disorders (ASD). Here we …

Recent evidence suggests potential, but unproven, links between dietary, metabolic,
infective, and gastrointestinal factors and the behavioral exacerbations and remissions of …

Clinical observations suggest that certain gut and dietary factors may transiently worsen
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …

Autism is a complex neurodevelopmental disorder which disrupts communication, social
and interactive skills followed by appearance of repetitive behavior. The underlying etiology …

In recent years increasing evidence has emerged suggesting that oxidative stress is
involved in the pathophysiology of a number of inherited metabolic disorders. However the …