Loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the
post-mortem caudate putamen (CPu) of Parkinson's disease (PD) patients. However, it is …

In the brain, the non‐essential amino acid L‐serine is produced through the phosphorylated
pathway (PP) starting from the glycolytic intermediate 3‐phosphoglycerate: among the …

L-Ser supply in the central nervous system of mammals mostly relies on its endogenous
biosynthesis by the phosphorylated pathway (PP). Defects in any of the three enzymes …

The human flavoenzyme D‐aspartate oxidase (hDASPO) controls the level of D‐aspartate in
the brain, a molecule acting as an agonist of NMDA receptors and modulator of AMPA and …

In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-
phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate …

The non-essential amino acid L-serine is involved in a number of metabolic pathways and in
the brain its level is largely due to the biosynthesis from the glycolytic intermediate D-3 …

Abstract D‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent
conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the …

Glioblastoma multiforme (GBM) is one of the most aggressive tumors known to occur in the
brain. Metabolism is one of the driving factors enabling the successful proliferation of tumor …

In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-
phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate …