[HTML][HTML] The Flavivirus Non-Structural Protein 5 (NS5): Structure, Functions, and Targeting for Development of Vaccines and Therapeutics
Flaviviruses, including dengue (DENV), Zika (ZIKV), West Nile (WNV), Japanese
encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a …
encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a …
The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in …
P Chen, L Wu, J Lei, F Chen, L Feng, G Liu… - International …, 2024 - Elsevier
The current study aimed to evaluate the preventive effects of urolithin C (Uro C), a gut
microbial metabolite of ellagitannins on D-galactose (D-gal)-induced brain damage during …
microbial metabolite of ellagitannins on D-galactose (D-gal)-induced brain damage during …
Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2
The ZIKA virus (ZIKV) evades the host immune response by degrading STAT2 through its
NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However …
NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However …
Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates
EJ Fay, K Isterabadi, CM Rezanka, J Le… - …, 2024 - pmc.ncbi.nlm.nih.gov
Receptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in
diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are …
diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are …
[HTML][HTML] Deciphering the molecular landscape of dengue infection: Insights from gene expression profiling and Protein Interactions
AS Alwabli - The Microbe, 2024 - Elsevier
Dengue fever (DF) is a viral infection recognized as one of the most rapidly spreading vector-
borne diseases among humans. However, the molecular mechanisms underlying disease …
borne diseases among humans. However, the molecular mechanisms underlying disease …
Evolutionary and functional analyses reveal conserved and non-conserved functions of vertebrate RIP kinases
EJ Fay, K Isterabadi, CM Rezanka, J Le, MD Daugherty - bioRxiv, 2024 - biorxiv.org
Receptor interacting protein kinases (RIPKs) play important roles in diverse innate immune
signaling pathways. Despite this, some RIPK-associated proteins are absent in specific …
signaling pathways. Despite this, some RIPK-associated proteins are absent in specific …
Structural Dynamics of the Dengue Virus Non-structural 5 (NS5) Interactions with Promoter Stem Loop A (SLA)
The dengue virus (DENV) NS5 protein plays a central role in dengue viral RNA synthesis
which makes it an attractive target for antiviral drug development. DENV NS5 is known to …
which makes it an attractive target for antiviral drug development. DENV NS5 is known to …
SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation
N Wang, S Tan, M Wang, H Liu, S Han, Z Wu, J Ma… - bioRxiv, 2024 - biorxiv.org
The protein tyrosine phosphatase SHP-1 is a key negative regulator in cancer by
dephosphorylating multiple target molecules. Specially in the NFκB signaling, where …
dephosphorylating multiple target molecules. Specially in the NFκB signaling, where …
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IFN Human, HSTCM Kit - pblassaysci.com
Background Following secretion, Interferon Beta binds to type I interferon receptors on
proximal or distal cells activating the JAK1-STAT signaling pathway. Activation of this signal …
proximal or distal cells activating the JAK1-STAT signaling pathway. Activation of this signal …