ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Breast cancer is a heterogeneous disorder with different molecular subtypes and biological
characteristics for which there are diverse therapeutic approaches and clinical outcomes …

Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor
genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and …

Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …

Poly (ADP) ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous
recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment …

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of
increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to …

Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1
(DBC1), has been recently identified as a master regulator of transcriptional processes and …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of
synthetic lethality and offer great promise in the treatment of tumors with deficiencies in …

Purpose Imaging the PARP expression using 18F probes has been approved in clinical
trials. Nevertheless, hepatobiliary clearance of both 18F probes hindered their application in …

Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …