As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …

Vesicle‐mediated transcellular transport or simply “transcytosis” is a cellular process used to
shuttle macromolecules such as lipoproteins, antibodies, and albumin from one surface of a …

In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still
readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide …

Aims Retention of low-density lipoprotein (LDL) cholesterol beneath the arterial endothelium
initiates an inflammatory response culminating in atherosclerosis. Since the overlying …

An endothelial cell monolayer separates interstitia from blood and lymph, and determines
the bidirectional transfer of solutes and macromolecules across these biological spaces. We …

The vascular endothelium supplying the brain exhibits very low paracellular and
transcellular permeability and is a major constituent of the blood-brain barrier. High-density …