The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure.
Although hepatocyte cell death is considered to be the critical event in APAP-induced …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Background and aims Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except
for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted …

Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …