5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also
found increasingly in a plethora of RNA species, predominantly transfer RNAs, but …

Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …

RNA methylation is an important epigenetic modification. Recent studies on RNA
methylation mainly focus on the m6A modification of mRNA, but very little is known about the …

Abstract Background 5-Methylcytosine (m 5 C) is a prevalent base modification in tRNA and
rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it …

NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a
posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the …

Posttranscriptional modifications in RNA have been considered to contribute to disease
pathogenesis and tumor progression. NOL1/NOP2/Sun domain family member 2 (NSUN2) …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

Epigenetic processes including RNA methylation, post-translational modifications, and non-
coding RNA expression have been associated with the heritable risks of systemic lupus …