Biofilm formed by several pathogenic bacteria results in the development of resistance
against antimicrobial compounds. The polymeric materials present in the biofilm architecture …

Many deadly infections are produced by microorganisms capable of sustained survival in
macrophages. This reduces exposure to chemadrotherapy, prevents immune detection, and …

Osteomyelitis, or the infection of the bone, presents a major complication in orthopedics and
may lead to prolonged hospital visits, implant failure, and in more extreme cases …

Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and
is now being investigated as a medium for local, prolonged drug delivery. Effective local …

Background Orthopaedic biomaterials are susceptible to biofilm formation. A novel lipid-
based material has been developed that may be loaded with antibiotics and applied as an …

We used in vitro and in vivo models of catheter-associated biofilm formation to compare the
relative activity of antibiotics effective against methicillin-resistant Staphylococcus aureus …

We used a murine model of acute, posttraumatic osteomyelitis to evaluate the virulence of
two divergent Staphylococcus aureus clinical isolates (the USA300 strain LAC and the …

Musculoskeletal disorders are a significant burden on the global economy and public health.
Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise …

The present investigation aims to study the chitosan sponge as a carrier matrix for the
sustained antibiotic release system for the prophylaxis of orthopedic implant-associated …

Amphotericin B (AmB) is an antifungal and antiparasitic agent that is the main drug used for
the treatment of mycoses infections and leishmaniasis. However, its high toxicity and side …