The remarkable processes that characterize living organisms, such as motility, self-healing
and reproduction, are fuelled by a continuous injection of energy at the microscale. The field …

The recent convergence between physics and biology has led many physicists to enter the
fields of cell and developmental biology. One of the most exciting areas of interest has been …

Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …

The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …

Nuclear compartmentalization of active and inactive chromatin is thought to occur through
microphase separation mediated by interactions between loci of similar type. The nature and …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in
yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair …

DNA is organized into chromatin, a complex polymeric material which stores information and
controls gene expression. An emerging mechanism for biological organization, particularly …

Active matter agents consume internal energy or extract energy from the environment for
locomotion and force generation. Already, rather generic models, such as ensembles of …

Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …