Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Antibiotics as antibacterial drugs have saved many lives, but have also become a victim of
their own success. Their widespread abuse reduces their anti-infective effectiveness and …

Antimicrobial prescription in critically ill patients represents a complex challenge due to the
difficult balance between infection treatment and toxicity prevention. Underexposure to …

Sepsis is a leading cause of disability and mortality worldwide. The pathophysiology of
sepsis relies on the maladaptive host response to pathogens that fosters unbalanced organ …

Inappropriate use of antibiotics is contributing to a serious antimicrobial resistance problem
in Asian hospitals. Despite resource constraints in the region, all Asian hospitals should …

Damage control orthopaedics (DCO) originally consisted of the provisional immobilisation of
long bone-mainly femur-fractures in order to achieve the advantages of early treatment and …