Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

The concept of liquid biopsy as an analysis tool for non-solid tissue carried out for the
purpose of providing information about solid tumors was introduced approximately 20 years …

POLE/POLD1 gene variants have been suggested as potential markers for immunotherapy
due to their significant association with the tumor mutational burden (TMB), an effective …

Colorectal cancer (CRC) is a highly lethal disease worldwide. The majority of patients
receiving targeted therapy or chemotherapy develop drug resistance, while its molecular …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in both
men and women. The ability of cancer cells to break-off from the primary tumor and spread …

The objective was to explore the function of gene differential expressions between lung
cancer tissues and the interaction between the relevant encoded proteins, thereby analyzing …

The concept of liquid biopsy as an analysis tool for non-solid tissue carried out for the
purpose of providing information about solid tumors was introduced approximately 20 years …

Colorectal cancer is one of the most common malignant tumors worldwide, responsible for
the second and fourth highest mortality among men and women, respectively(1, 2). Standard …

I would firstly like to thank my supervisors Prof. David Gonzalez de Castro and Prof. Manuel
Salto-Tellez for giving me the opportunity to complete my PhD and for all of their support this …