Fungi have the ability to transform organic materials into a rich and diverse set of useful
products and provide distinct opportunities for tackling the urgent challenges before all …

Chinese hamster ovary (CHO) cells are the most widely used mammalian host cells for the
commercial production of therapeutic proteins. Fed-batch culture is widely used to produce …

Therapeutic antibody technology heavily dominates the biologics market and continues to
present as a significant industrial interest in developing novel and improved antibody …

BACKGROUND Tangential flow filtration (TFF) systems are widely used cell retention
devices in perfusion cultures, but significant challenges occur with their prolonged …

Filamentous fungi have been harnessed for the production of organic acids, antibiotics,
drugs, and enzymes for the last 100 years. Fungal biotechnology is currently undergoing a …

Chinese hamster ovary (CHO) cells are the most widely used mammalian host for industrial-
scale production of monoclonal antibodies (mAbs) and other protein biologics. Isolation of …

Mammalian cells are the preferred choice system for the production of complex molecules,
such as recombinant therapeutic proteins. Although the technology for increasing the yield …

Native flexibly linked (NFL) HIV-1 envelope glycoprotein (Env) trimers are cleavage-
independent and display a native-like, well-folded conformation that preferentially displays …

The Chinese hamster ovary (CHO) cell line is the most widely used host cell for therapeutic
antibody production. Although its productivity has been improved by various strategies to …

Secreted recombinant proteins can aggregate during cell culture. We studied a poorly-
behaved bispecific scaffold that increasingly aggregated (up to 62% high molecular weight …