Designing the next generation of vaccines for global public health

F Bagnoli, B Baudner, RPN Mishra… - Omics: a journal of …, 2011 - liebertpub.com
Vaccine research and development are experiencing a renaissance of interest from the
global scientific community. There are four major reasons for this:(1) the lack of efficacious …

Evolved to vary: genome and epigenome variation in the human pathogen Helicobacter pylori

F Ailloud, I Estibariz, S Suerbaum - FEMS Microbiology Reviews, 2021 - academic.oup.com
Helicobacter pylori is a Gram-negative, spiral shaped bacterium that selectively and
chronically infects the gastric mucosa of humans. The clinical course of this infection can …

[HTML][HTML] Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps

F Ailloud, X Didelot, S Woltemate, G Pfaffinger… - Nature …, 2019 - nature.com
The human pathogen Helicobacter pylori displays extensive genetic diversity. While H.
pylori is known to evolve during infection, population dynamics inside the gastric …

Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine

A Fritzer, BM Senn, DB Minh, M Hanner… - Infection and …, 2010 - Am Soc Microbiol
Group A streptococci (GAS) can cause a wide variety of human infections ranging from
asymptomatic colonization to life-threatening invasive diseases. Although antibiotic …

In Vivo Sequence Variation in HopZ, a Phase-Variable Outer Membrane Protein of Helicobacter pylori

L Kennemann, B Brenneke, S Andres… - Infection and …, 2012 - Am Soc Microbiol
The Helicobacter pylori outer membrane protein HopZ is regulated by a phase-variable CT
repeat and occurs in two distinct allelic variants. Whole-genome comparisons of isolates …

Identification and characterization of antigens as vaccine candidates against Klebsiella pneumoniae

U Lundberg, BM Senn, W Schüler… - Human Vaccines & …, 2013 - Taylor & Francis
Nosocomial infections, also called “hospital acquired infections,” occur worldwide and affect
both developed and resource-poor countries, thus having a major impact on their health …

Inflammation, Immunity, and Vaccines for Helicobacter

T Aebischer, TF Meyer, LP Andersen - Helicobacter, 2010 - Wiley Online Library
Helicobacter pylori represents the major etiologic agent of gastritis, gastric, and duodenal
ulcer disease and can cause gastric cancer and mucosa‐associated lymphoid tissue B‐cell …

[HTML][HTML] Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease

JA Bugaytsova, K Moonens, A Piddubnyi, A Schmidt… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The majority of the world population carry the gastric pathogen Helicobacter pylori.
Fortunately, most individuals experience only low-grade or no symptoms, but in many cases …

[HTML][HTML] Comprehensive Antigen Screening Identifies Moraxella catarrhalis Proteins That Induce Protection in a Mouse Pulmonary Clearance Model

M Smidt, P Bättig, SJC Verhaegh, A Niebisch… - PLoS …, 2013 - journals.plos.org
Moraxella catarrhalis is one of the three most common causative bacterial pathogens of otitis
media, however no effective vaccine against M. catarrhalis has been developed so far. To …

[HTML][HTML] Defining the Helicobacter pylori Disease-Specific Antigenic Repertoire

MF Soluri, S Puccio, G Caredda, P Edomi… - Frontiers in …, 2020 - frontiersin.org
The analysis of the interaction between Helicobacter pylori (HP) and the host in vivo is an
extremely informative way to enlighten the molecular mechanisms behind the …