Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …
Perifosine–a new option in treatment of acute myeloid leukemia?
J Krawczyk, N Keane, R Swords… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Perifosine is a novel targeted oral Akt inhibitor. In preclinical leukemia models,
perifosine has an independent cytotoxic potential but also synergizes well with other …
perifosine has an independent cytotoxic potential but also synergizes well with other …
Modeling the cancer stem cell hypothesis
C Calmelet, A Prokop, J Mensah… - … Modelling of Natural …, 2010 - cambridge.org
Solid tumors and hematological cancers contain small population of tumor cells that are
believed to play a critical role in the development and progression of the disease. These …
believed to play a critical role in the development and progression of the disease. These …
[PDF][PDF] Rapid it:-4537353
A Prokop - researchgate.net
Solid tumors and hematological cancers contain small population of tumor cells that are
believed to play a critical role in the development and progression of the disease. These …
believed to play a critical role in the development and progression of the disease. These …
[HTML][HTML] Plc Signaling
J Krawczyk, N Keane, R Swords… - Expert Opin. Investig …, 2013 - plcsignaling.com
Introduction: Perifosine is a novel targeted oral Akt inhibitor. In preclinical leukemia models,
perifosine has an independent cytotoxic potential but also synergizes well with other …
perifosine has an independent cytotoxic potential but also synergizes well with other …
[HTML][HTML] Avapritinib Inhibitor
J Krawczyk, N Keane, R Swords… - Expert Opin …, 2013 - avapritinibinhibitor.com
Introduction: Perifosine is a novel targeted oral Akt inhibitor. In preclinical leukemia models,
perifosine has an independent cytotoxic potential but also synergizes well with other …
perifosine has an independent cytotoxic potential but also synergizes well with other …