Lipoprotein lipase
M Merkel, RH Eckel, IJ Goldberg - Journal of lipid research, 2002 - ASBMB
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects
are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and …
are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and …
[PDF][PDF] Lipoprotein lipase: physiology, biochemistry, and molecular biology
IJ Goldberg, M Merkel - Front Biosci, 2001 - article.imrpress.com
[Frontiers in Bioscience 6, d388-405, March 1, 2001] 388 LIPOPROTEIN LIPASE:
PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR BIOLOGY Ira Page 1 [Frontiers in …
PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR BIOLOGY Ira Page 1 [Frontiers in …
Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia
RP Surendran, ME Visser, S Heemelaar… - Journal of internal …, 2012 - Wiley Online Library
Surendran RP, Visser ME, Heemelaar S, Wang J, Peter J, Defesche JC, Kuivenhoven JA,
Hosseini M, Péterfy M, Kastelein JJP, Johansen CT, Hegele RA, Stroes ESG, Dallinga‐Thie …
Hosseini M, Péterfy M, Kastelein JJP, Johansen CT, Hegele RA, Stroes ESG, Dallinga‐Thie …
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
Lipoprotein lipase plays a central role in lipid metabolism and the gene that encodes this
enzyme (LPL) is a candidate susceptibility gene for cardiovascular disease. Here we report …
enzyme (LPL) is a candidate susceptibility gene for cardiovascular disease. Here we report …
Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation
J Rip, MC Nierman, CJ Ross, JW Jukema… - … , and vascular biology, 2006 - Am Heart Assoc
Lipoprotein lipase (LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic
uptake of remnant lipoproteins. Since the gene was cloned in 1989, more than 100 LPL …
uptake of remnant lipoproteins. Since the gene was cloned in 1989, more than 100 LPL …
Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis
RM Fisher, SE Humphries, PJ Talmud - Atherosclerosis, 1997 - Elsevier
The importance of the enzyme lipoprotein lipase (LPL) in the development of dyslipidaemia
and atherosclerosis is increasingly recognised. Variations in the LPL gene which are …
and atherosclerosis is increasingly recognised. Variations in the LPL gene which are …
Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the …
SE Humphries, V Nicaud, J Margalef… - … , and vascular biology, 1998 - Am Heart Assoc
The H-allele of the intron 8 Hin dIII polymorphism in the lipoprotein lipase (LPL) gene has
been associated with a lower risk of myocardial infarction (MI) and plasma levels of …
been associated with a lower risk of myocardial infarction (MI) and plasma levels of …
Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins
HE Henderson, JJP Kastelein, AH Zwinderman… - Journal of lipid …, 1999 - ASBMB
Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich
lipoproteins in the formation of HDL particles. As both these lipoproteins play an important …
lipoproteins in the formation of HDL particles. As both these lipoproteins play an important …
A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study
SE Gagne, MG Larson, SN Pimstone… - Clinical …, 1999 - Wiley Online Library
Genetic variation at the lipoprotein lipase (LPL) locus has been shown to influence plasma
lipids and to modulate risk of coronary heart disease (CHD). Recently, we found that the …
lipids and to modulate risk of coronary heart disease (CHD). Recently, we found that the …
Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site
K Richardson, JA Nettleton, N Rotllan, T Tanaka… - The American Journal of …, 2013 - cell.com
Genome-wide association studies (GWAS) have identified hundreds of genetic variants that
are associated with lipid phenotypes. However, data supporting a functional role for these …
are associated with lipid phenotypes. However, data supporting a functional role for these …