Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Arterial stiffness results from a degenerative process affecting mainly the extracellular matrix
of elastic arteries under the effect of aging and risk factors. Changes in extracellular matrix …

Aims To determine the effects of empagliflozin on blood pressure (BP) and markers of
arterial stiffness and vascular resistance in patients with type 2 diabetes mellitus (T2DM) …

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

Prevention of cardiovascular disease (CVD) remains one of the largest public health
challenges of our time. Identifying individuals at increased cardiovascular risk at an …

Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …

Arterial stiffness is a major independent risk factor for cardiovascular complications causing
isolated systolic hypertension and increased pulse pressure in the microvasculature of …