Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Abstract Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the
hypothalamus represent key regulators of metabolic homeostasis. Electrophysiological and …

Insulin acts on neurons and glial cells to regulate systemic glucose metabolism and feeding.
However, the mechanisms of insulin access in discrete brain regions are incompletely …

Internal states of the brain profoundly influence behavior. Fluctuating states such as
alertness can be governed by neuromodulation, but the underlying mechanisms and cell …

Highlights•Discrete neuronal populations are sufficient for driving appetite and
satiety.•These neurons are regulated by sensory, hormonal, and exogenous …

Glucose is the essential energy source for the brain, whose deficit, triggered by energy
deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral …

Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to
energy deficits and play a key role in the control of feeding behavior and metabolism. Here …

Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is
targeted by several anti-obesity drugs. To better understand the circuitry underlying …

The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including
among pregnant women. Low-calorie sweeteners (LCSs) have increasingly been used as …