Model membrane systems and their applications

YHM Chan, SG Boxer - Current opinion in chemical biology, 2007 - Elsevier
The complexity of biological membranes has motivated the development of a wide variety of
simpler model systems whose size, geometry, and composition can be tailored with great …

Applications of biological pores in nanomedicine, sensing, and nanoelectronics

S Majd, EC Yusko, YN Billeh, MX Macrae… - Current opinion in …, 2010 - Elsevier
Biological protein pores and pore-forming peptides can generate a pathway for the flux of
ions and other charged or polar molecules across cellular membranes. In nature, these …

How curved membranes recruit amphipathic helices and protein anchoring motifs

NS Hatzakis, VK Bhatia, J Larsen, KL Madsen… - Nature chemical …, 2009 - nature.com
Lipids and several specialized proteins are thought to be able to sense the curvature of
membranes (MC). Here we used quantitative fluorescence microscopy to measure curvature …

Single-vesicle assays using liposomes and cell-derived vesicles: from modeling complex membrane processes to synthetic biology and biomedical applications

H Pick, AC Alves, H Vogel - Chemical reviews, 2018 - ACS Publications
The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …

Microfabricated arrays of femtoliter chambers allow single molecule enzymology

Y Rondelez, G Tresset, KV Tabata, H Arata… - Nature …, 2005 - nature.com
Precise understanding of biological functions requires tools comparable in size to the basic
components of life,,,. Single molecule studies have revealed molecular behaviors usually …

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

VK Bhatia, KL Madsen, PY Bolinger, A Kunding… - The EMBO …, 2009 - embopress.org
BAR (Bin/Amphiphysin/Rvs) domains and amphipathic α‐helices (AHs) are believed to be
sensors of membrane curvature thus facilitating the assembly of protein complexes on …

DNA-induced programmable fusion of phospholipid vesicles

G Stengel, R Zahn, F Höök - Journal of the American Chemical …, 2007 - ACS Publications
In nature, the fusion of phospholipid vesicles is regulated and catalyzed by highly
specialized SNARE proteins. A key step in this process is to bring about close apposition of …

Liposome and lipid bilayer arrays towards biosensing applications

M Bally, K Bailey, K Sugihara, D Grieshaber, J Vörös… - Small, 2010 - Wiley Online Library
Sensitive and selective biosensors for high‐throughput screening are having an increasing
impact in modern medical care. The establishment of robust protein biosensing platforms …

Bivalent cholesterol-based coupling of oligonucletides to lipid membrane assemblies

I Pfeiffer, F Höök - Journal of the American Chemical Society, 2004 - ACS Publications
By mimicking Nature's way of utilizing multivalent interactions, we introduce in the present
work a novel method to improve the strength of cholesterol-based DNA coupling to lipid …

Microfluidics for processing surfaces and miniaturizing biological assays

E Delamarche, D Juncker, H Schmid - Advanced Materials, 2005 - Wiley Online Library
This review is an account of our efforts to develop a versatile and flexible microfluidic
technology for surface‐processing applications and miniaturizing biological assays. The …