Tumor microenvironment signaling and therapeutics in cancer progression
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
Peptides as multifunctional players in cancer therapy
SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …
[HTML][HTML] Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death
Rationale: Cancer immunotherapy combining immune checkpoint blockade (ICB) with
chemotherapeutic drugs has provided significant clinical advances. However, such …
chemotherapeutic drugs has provided significant clinical advances. However, such …
Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
Y Lin, M Yan, Z Bai, Y Xie, L Ren, J Wei, D Zhu… - Journal of …, 2022 - Springer
Background Effective therapeutics to stop or reverse liver fibrosis have not emerged,
because these potential agents cannot specifically target activated hepatic stellate cells …
because these potential agents cannot specifically target activated hepatic stellate cells …
An In Vivo Self‐Assembled Bispecific Nanoblocker for Enhancing Tumor Immunotherapy
XJ Hu, NY Zhang, DY Hou, ZJ Wang… - Advanced …, 2023 - Wiley Online Library
Anti‐PD‐L1 monoclonal antibody has achieved substantial success in tumor
immunotherapy by T‐cells activation. However, the excessive accumulation of extracellular …
immunotherapy by T‐cells activation. However, the excessive accumulation of extracellular …
[HTML][HTML] Natural peptides for immunological regulation in cancer therapy: mechanism, facts and perspectives
Y Zhang, C Liu, C Wu, L Song - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cancer incidence and mortality rates are increasing annually. Treatment with surgery,
chemotherapy and radiation therapy (RT) is unsatisfactory because many patients have …
chemotherapy and radiation therapy (RT) is unsatisfactory because many patients have …
[HTML][HTML] NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma
F Lu, Y Zhao, Y Pang, M Ji, Y Sun, H Wang, J Zou… - Cancer letters, 2021 - Elsevier
The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However,
its potential role in lymphomagenesis remains unclear. In this study, we identified an …
its potential role in lymphomagenesis remains unclear. In this study, we identified an …
Bioactive peptide nanodrugs based on supramolecular assembly for boosting immunogenic cell death‐induced cancer immunotherapy
Y Liu, R Chang, R Xing, X Yan - Small Methods, 2023 - Wiley Online Library
Immunogenic cell death (ICD)‐induced immunotherapy holds promise for complete
elimination and long‐term protective immune responses against cancer by combining direct …
elimination and long‐term protective immune responses against cancer by combining direct …
[HTML][HTML] Immunogenic cell death inducer peptides: A new approach for cancer therapy, current status and future perspectives
Abstract Immunogenic Cell Death (ICD) is a type of cell death that kills tumor cells by
stimulating the adaptive immune response against other tumor cells. ICD depends on the …
stimulating the adaptive immune response against other tumor cells. ICD depends on the …
Bio-orthogonal click chemistry strategy for PD-L1-targeted imaging and pyroptosis-mediated chemo-immunotherapy of triple-negative breast cancer
Y Wang, Y Chen, DK Ji, Y Huang, W Huang… - Journal of …, 2024 - Springer
Background The combination of programmed cell death ligand-1 (PD-L1) immune
checkpoint blockade (ICB) and immunogenic cell death (ICD)-inducing chemotherapy has …
checkpoint blockade (ICB) and immunogenic cell death (ICD)-inducing chemotherapy has …