Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …

Compromised alveolar development and pulmonary vascular remodeling are hallmarks of
pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary …

Activation of oncogenic gene expression from long-range enhancers is initiated by the
assembly of DNA-binding transcription factors (TF), leading to recruitment of co-activators …

Background and purpose Proton radiotherapy (PRT) offers potential benefits over other
radiation modalities, including photon and electron radiotherapy. Increasing the rate at …

Gene transcription does not only require writers of active histone modifications; on-site
opposition by erasers is essential for many genes. Here, we propose the concept of dynamic …

Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is
linked to heterozygous mutations in the FOXF1 (Forkhead Box F1) gene, a key …

Barth syndrome (BTHS) is a rare disorder caused by mutations in the TAFAZZIN gene.
Previous studies from both patients and model systems have established metabolic …

Rhabdomyosarcoma (RMS) is a highly metastatic soft-tissue sarcoma that often develops
resistance to current therapies, including vincristine. Since the existing treatments have not …

Cancer cells re-program normal lung endothelial cells (EC) into tumor-associated
endothelial cells (TEC) that form leaky vessels supporting carcinogenesis. Transcriptional …