The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Nerolidol: a sesquiterpene alcohol with multi-faceted pharmacological and biological activities

WK Chan, LTH Tan, KG Chan, LH Lee, BH Goh - Molecules, 2016 - mdpi.com
Nerolidol (3, 7, 11-trimethyl-1, 6, 10-dodecatrien-3-ol) is a naturally occurring sesquiterpene
alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate …

Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives

T Nasr, S Bondock, M Youns - European journal of medicinal chemistry, 2014 - Elsevier
Drug resistance is a major impediment for cancer treatment, to overcome it we designed and
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …

Plant-derived bioactives and oxidative stress-related disorders: a key trend towards healthy aging and longevity promotion

B Salehi, E Azzini, P Zucca, E Maria Varoni… - Applied Sciences, 2020 - mdpi.com
Plants and their corresponding botanical preparations have been used for centuries due to
their remarkable potential in both the treatment and prevention of oxidative stress-related …

[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future

A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu… - Journal of …, 2012 - Elsevier
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …

Toxicities by herbal medicines with emphasis to traditional Chinese medicine

T Efferth, B Kaina - Current drug metabolism, 2011 - ingentaconnect.com
It is estimated that three quarters of the world population rely on herbal and traditional
medicine as a basis for primary health care. Therefore, it is one of the most important and …

[HTML][HTML] Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

M Ouedraogo, T Baudoux, C Stévigny, J Nortier… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …

Screening of herbal medicines for potential toxicities

O Ifeoma, S Oluwakanyinsola - New insights into toxicity and drug …, 2013 - books.google.com
Herbs and herb-derived medicines have played a crucial role in health and disease man‐-
agement for many centuries. Many ancient civilizations show documented evidence for the …

Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

T Efferth, F Oesch - Seminars in Cancer Biology, 2021 - Elsevier
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic …

T Nasr, S Bondock, HM Rashed, W Fayad… - European journal of …, 2018 - Elsevier
The current work presents the synthesis and biological evaluation of new series of coumarin
hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities …