The re-emergence of natural products for drug discovery in the genomics era
AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
Nerolidol: a sesquiterpene alcohol with multi-faceted pharmacological and biological activities
Nerolidol (3, 7, 11-trimethyl-1, 6, 10-dodecatrien-3-ol) is a naturally occurring sesquiterpene
alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate …
alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate …
Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives
Drug resistance is a major impediment for cancer treatment, to overcome it we designed and
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …
synthesized sixteen coumarins bearing hydrazide–hydrazone moiety and evaluated them …
Plant-derived bioactives and oxidative stress-related disorders: a key trend towards healthy aging and longevity promotion
Plants and their corresponding botanical preparations have been used for centuries due to
their remarkable potential in both the treatment and prevention of oxidative stress-related …
their remarkable potential in both the treatment and prevention of oxidative stress-related …
[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future
A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu… - Journal of …, 2012 - Elsevier
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …
Toxicities by herbal medicines with emphasis to traditional Chinese medicine
T Efferth, B Kaina - Current drug metabolism, 2011 - ingentaconnect.com
It is estimated that three quarters of the world population rely on herbal and traditional
medicine as a basis for primary health care. Therefore, it is one of the most important and …
medicine as a basis for primary health care. Therefore, it is one of the most important and …
[HTML][HTML] Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
M Ouedraogo, T Baudoux, C Stévigny, J Nortier… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …
medicines around the world requires more scientific evidence for their putative …
Screening of herbal medicines for potential toxicities
O Ifeoma, S Oluwakanyinsola - New insights into toxicity and drug …, 2013 - books.google.com
Herbs and herb-derived medicines have played a crucial role in health and disease man‐-
agement for many centuries. Many ancient civilizations show documented evidence for the …
agement for many centuries. Many ancient civilizations show documented evidence for the …
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …
treatment indications. Phytochemicals isolated from medicinal plants have been largely …
Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic …
The current work presents the synthesis and biological evaluation of new series of coumarin
hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities …
hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities …