From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation

K Howick, BT Griffin, JF Cryan… - International journal of …, 2017 - mdpi.com
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

Unraveling the central proopiomelanocortin neural circuits

AJ Mercer, ST Hentges, CK Meshul… - Frontiers in …, 2013 - frontiersin.org
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our
understanding of the integration of this hypothalamic circuit throughout the central nervous …

[HTML][HTML] Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016

MD Ericson, CJ Lensing, KA Fleming… - … et Biophysica Acta (BBA …, 2017 - Elsevier
The discovery of the endogenous melanocortin agonists in the 1950s have resulted in sixty
years of melanocortin ligand research. Early efforts involved truncations or select …

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

JD Mul, R Van Boxtel, DJM Bergen, MAD Brans… - …, 2012 - Wiley Online Library
Obesity is caused by an imbalance between energy intake and expenditure and has
become a major health‐care problem in western society. The central melanocortin system …

The multifunctional human ocular melanocortin system

CLS Wu, AV Cioanca, MC Gelmi, L Wen… - Progress in Retinal and …, 2023 - Elsevier
Immune privilege in the eye involves physical barriers, immune regulation and secreted
proteins that together limit the damaging effects of intraocular immune responses and …

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

MD Ericson, SM Schnell, KT Freeman… - Bioorganic & medicinal …, 2015 - Elsevier
The melanocortin system consists of five receptor subtypes (MC1–5R), endogenous
agonists derived from the proopiomelanocortin gene transcript, and the antagonists agouti …

Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral …

K Begriche, PR Levasseur, J Zhang, J Rossi… - Journal of Biological …, 2011 - ASBMB
The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition,
natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs …

Neuronal cAMP/PKA signaling and energy homeostasis

L Yang - Neural Regulation of Metabolism, 2018 - Springer
The brain plays a key role in the regulation of body weight and glucose metabolism.
Peripheral signals including hormones, metabolites, and neural afferent signals are …

An in vitro and in vivo investigation of bivalent ligands that display preferential binding and functional activity for different melanocortin receptor homodimers

CJ Lensing, KT Freeman, SM Schnell… - Journal of medicinal …, 2016 - ACS Publications
Pharmacological probes for the melanocortin receptors have been utilized for studying
various disease states including cancer, sexual function disorders, Alzheimer's disease …

Mutations in melanocortin-3 receptor gene and human obesity

Z Yang, YX Tao - Progress in molecular biology and translational …, 2016 - Elsevier
The prevalence of obesity calls for novel therapeutic targets. The melanocortin-3 receptor
(MC3R) has been increasingly recognized as an important regulator of energy homeostasis …