[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

[HTML][HTML] Pros and cons of ultra-high-field MRI/MRS for human application

ME Ladd, P Bachert, M Meyerspeer, E Moser… - Progress in nuclear …, 2018 - Elsevier
Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

MP Moore, RP Cunningham, GM Meers… - …, 2022 - Wiley Online Library
Background and Aims NAFLD and its more‐advanced form, steatohepatitis (NASH), is
associated with obesity and is an independent risk factor for cardiovascular, liver‐related …

NAFLD and diabetes mellitus

H Tilg, AR Moschen, M Roden - Nature reviews Gastroenterology & …, 2017 - nature.com
The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

[HTML][HTML] Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis

MV Pinti, GK Fink, QA Hathaway… - American Journal …, 2019 - journals.physiology.org
Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

[HTML][HTML] Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

C Koliaki, J Szendroedi, K Kaul, T Jelenik, P Nowotny… - Cell metabolism, 2015 - cell.com
The association of hepatic mitochondrial function with insulin resistance and non-alcoholic
fatty liver (NAFL) or steatohepatitis (NASH) remains unclear. This study applied high …

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

RJ Perry, VT Samuel, KF Petersen, GI Shulman - Nature, 2014 - nature.com
Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis

M Apostolopoulou, R Gordillo, C Koliaki… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Insulin resistance and nonalcoholic fatty liver disease have been linked to
several lipid metabolites in animals, but their role in humans remains unclear. This study …