In the last few decades, there has been a growing interest in Bruton's tyrosine kinase (BTK)
and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) …

The tumor microenvironment (TME) plays an essential role in the development, growth, and
survival of the malignant B-cell clone in chronic lymphocytic leukemia (CLL). Within the …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …

Simple Summary The availability of Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has
undoubtedly reshaped the initial management of chronic lymphocytic leukemia (CLL) …

Bruton's tyrosine kinase (BTK) regulates multiple important signaling pathways and plays a
key role in the proliferation, survival, and differentiation of B-lineage cells and myeloid cells …

The approval of BTK and PI3K inhibitors (ibrutinib, idelalisib) represents a revolution in the
therapy of B cell malignancies such as chronic lymphocytic leukemia (CLL), mantle-cell …

Despite significant efficacy, one of the major limitations of small-molecule Bruton's tyrosine
kinase (BTK) agents is the presence of clinically acquired resistance, which remains a major …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Bruton tyrosine kinase (BTK) is an important signaling hub that activates the B-cell receptor
(BCR) signaling cascade. BCR activation can contribute to the growth and survival of B-cell …

Mantle cell lymphoma is a B cell non-Hodgkin lymphoma (NHL), representing 2–6% of all
NHLs and characterized by overexpression of cyclin D1. The last decade has seen the …