It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …

Histone deacetylase inhibitors are a large group of diverse molecules intrinsically able to
inhibit cell proliferation in various cancer cell lines. Their apoptotic effects have been linked …

The interest in histone deacetylase (HDACa) inhibitors began almost 30 years ago during
some studies designed to understand why dimethyl sulfoxide (DMSO) caused terminal …

The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …

Chemical manipulations performed on aroyl-pyrrolyl-hydroxyamides (APHAs) led to
(aryloxopropenyl) pyrrolyl hydroxamates 2a− w, and their inhibition against maize HDACs …

This paper reports the development of a series of 5-aroylindolyl-substituted hydroxamic
acids. N-Hydroxy-4-((5-(4-methoxybenzoyl)-1 H-indol-1-yl) methyl) benzamide (6) has …

Starting from a yeast phenotypic screening performed on 21 compounds, we described the
identification of two small molecules (9 and 18) able to significantly reduce the S. cerevisiae …

A number of new compounds bearing two ortho-bromo-and ortho, ortho-dibromophenol
moieties linked through a saturated/unsaturated, linear/(poly) cyclic spacer (compounds 1 …

After over 30 years of research, the development of HDAC inhibitors led to five FDA/Chinese
FDA-approved drugs and many others under clinical or preclinical investigation to treat …