[HTML][HTML] Brain-gut-microbiota axis in Alzheimer's disease
K Kowalski, A Mulak - Journal of neurogastroenterology and …, 2019 - ncbi.nlm.nih.gov
Disturbances along the brain-gut-microbiota axis may significantly contribute to the
pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent …
pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent …
Trained immunity: reprogramming innate immunity in health and disease
S Bekkering, J Domínguez-Andrés… - Annual review of …, 2021 - annualreviews.org
Traditionally, the innate and adaptive immune systems are differentiated by their specificity
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …
Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
A review of cytokine-based pathophysiology of Long COVID symptoms
RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …
Low-grade inflammation, diet composition and health: current research evidence and its translation
AM Minihane, S Vinoy, WR Russell, A Baka… - British Journal of …, 2015 - cambridge.org
The importance of chronic low-grade inflammation in the pathology of numerous age-related
chronic conditions is now clear. An unresolved inflammatory response is likely to be …
chronic conditions is now clear. An unresolved inflammatory response is likely to be …
Systemic inflammation and microglial activation: systematic review of animal experiments
ICM Hoogland, C Houbolt, DJ van Westerloo… - Journal of …, 2015 - Springer
Background Animal studies show that peripheral inflammatory stimuli may activate
microglial cells in the brain implicating an important role for microglia in sepsis-associated …
microglial cells in the brain implicating an important role for microglia in sepsis-associated …
Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba‐1 or GFAP immunoreactivity following systemic immune challenge
Activation of the peripheral immune system elicits a coordinated response from the central
nervous system. Key to this immune to brain communication is that glia, microglia, and …
nervous system. Key to this immune to brain communication is that glia, microglia, and …
Microglial priming in neurodegenerative disease
VH Perry, C Holmes - Nature Reviews Neurology, 2014 - nature.com
Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …
Microglia priming with aging and stress
The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …
and socio-economic implications. Clinical and experimental studies on aging have …
Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
VH Perry, J Teeling - Seminars in immunopathology, 2013 - Springer
Microglia, the resident immune cells of the central nervous system (CNS), play an important
role in CNS homeostasis during development, adulthood and ageing. Their phenotype and …
role in CNS homeostasis during development, adulthood and ageing. Their phenotype and …