Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

534 Hypertension September 2016 vasodilation is unrelated to the tissue kallikrein–kinin
system. 18 In addition, kallistatin transgenic mice were found to have significantly lower …

Kallistatin is a unique serine proteinase inhibitor (serpin) and a heparin-binding protein. It
has been localized in vascular smooth muscle cells and endothelial cells of human blood …

Kallistatin, an endogenous protein, protects against vascular injury by inhibiting oxidative
stress and inflammation in hypertensive rats and enhancing the mobility and function of …

Kallistatin, an endogenous protein, consists of two structural elements: active site and
heparin-binding domain. Kallistatin exerts beneficial effects on fibrosis by suppressing …

Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial
cells and modulates vascular homeostasis through interactions with multiple Heparan …

Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining
hemostatic balance under physiological conditions. Any deviation from these pathways …

Kallistatin is a regulator of vascular homeostasis capable of controlling a wide spectrum of
biological actions in the cardiovascular and renal systems. We previously reported that …

Wound healing, angiogenesis, and hair follicle maintenance are often impaired in the skin of
diabetic patients, but the pathogenesis has not been well understood. Here, we report that …

Kallistatin is a plasma protein with anti-inflammatory properties. In this study, we investigated
the role and mechanisms of kallistatin in inhibiting endothelial inflammation through its …