Cytosine methylation determines hot spots of DNA damage in the human P53 gene
MF Denissenko, JX Chen, M Tang… - Proceedings of the …, 1997 - National Acad Sciences
In the P53 tumor suppressor gene, a remarkably large number of somatic mutations are
found at methylated CpG dinucleotides. We have previously mapped the distribution of (±) …
found at methylated CpG dinucleotides. We have previously mapped the distribution of (±) …
UVB‐induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53
R Drouin, JP Therrien - Photochemistry and photobiology, 1997 - Wiley Online Library
Ultraviolet light has been identified as the major carcinogen in skin cancer and the p53
tumor suppressor gene is a major target for UV‐induced mutations. The mutations are …
tumor suppressor gene is a major target for UV‐induced mutations. The mutations are …
Filtering small nucleic acids using permeabilized cells
Y Kong, ST Okino, X Meng - US Patent 8,728,987, 2014 - Google Patents
US8728987B2 - Filtering small nucleic acids using permeabilized cells - Google Patents
US8728987B2 - Filtering small nucleic acids using permeabilized cells - Google Patents Filtering …
US8728987B2 - Filtering small nucleic acids using permeabilized cells - Google Patents Filtering …
Rapid deamination of cyclobutane pyrimidine dimer photoproducts at TCG sites in a translationally and rotationally positioned nucleosome in vivo
VJ Cannistraro, S Pondugula, Q Song… - Journal of Biological …, 2015 - ASBMB
Sunlight-induced C to T mutation hot spots in skin cancers occur primarily at methylated
CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) …
CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) …
Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean
Ultraviolet (UV) radiation can produce biological damage, leading the cell to apoptosis by
the p53 pathway. This study evaluated some molecular markers of the apoptosis pathway …
the p53 pathway. This study evaluated some molecular markers of the apoptosis pathway …
Synergistic modulation of cyclobutane pyrimidine dimer photoproduct formation and deamination at a TmCG site over a full helical DNA turn in a nucleosome core …
Q Song, VJ Cannistraro, JS Taylor - Nucleic acids research, 2014 - academic.oup.com
Sunlight-induced C to T mutation hotspots in skin cancers occur primarily at methylated CpG
sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation …
sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation …
In silico p53 mutation hotspots in lung cancer
PD Lewis, JM Parry - Carcinogenesis, 2004 - academic.oup.com
For cancer one of the primary aims of molecular epidemiology is to identify the endogenous
or exogenous cause of mutations within a gene. Regarding exogenous mutagens, many …
or exogenous cause of mutations within a gene. Regarding exogenous mutagens, many …
In vivo DNA analysis
R Drouin, JP Therrien, M Angers, S Ouellet - DNA-Protein Interactions …, 2001 - Springer
The in vivo analysis of DNA-protein interactions and chromatin structure can provide several
kinds of critical information regarding regulation of gene expression and gene function. For …
kinds of critical information regarding regulation of gene expression and gene function. For …
Binding and Reaction of calicheamicin and other enediyne antibiotics with DNA
JP Cosgrove, PC Dedon - … and RNA binders: from synthesis to …, 2002 - Wiley Online Library
The US Food and Drug Adminstration recently approved the use of gemtuzumab
ozogamicin for the treatment of relapsing acute myeloid leukemia [1, 2]. This antibody …
ozogamicin for the treatment of relapsing acute myeloid leukemia [1, 2]. This antibody …
Stereoselectivity of human nucleotide excision repair promoted by defective hybridization
MT Hess, H Naegeli, M Capobianco - Journal of Biological Chemistry, 1998 - ASBMB
To assess helical parameters that dictate fast or slow removal of carcinogen-DNA adducts,
we probed human nucleotide excision repair (NER) activity with DNA containingl …
we probed human nucleotide excision repair (NER) activity with DNA containingl …