Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron has the capacity to accept and donate electrons readily, interconverting between ferric
(Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of …

In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …

Before the introduction of erythropoiesis-stimulating agents (ESAs) in 1989, repeated
transfusions given to patients with end-stage renal disease caused iron overload, and the …

For many years, hereditary hemochromatosis was regarded as a clinically and genetically
unique entity marked by a classic presentation consisting of diabetes, bronze skin …

The widespread availability and frequent use of serum chemistry tests have resulted in a
dramatic increase in the number of normal and abnormal liver chemistry test values that …

The distinguishing feature between iron homeostasis in single versus multicellular
organisms is the need for multicellular organisms to transfer iron from sites of absorption to …

Haemochromatosis is a common recessive disorder characterized by progressive iron
overload, which may lead to severe clinical complications. Most patients are homozygous for …

Disorders that perturb iron balance are among the most prevalent human diseases, but until
recently iron transport remained poorly understood. Over the past five years, genetic studies …

Hereditary hemochromatosis (HHC) is an autosomal recessive disorder of iron metabolism
characterized by increased iron absorption and deposition in the liver, pancreas, heart …