State-of-the-Art-Review: mechanisms of action of SGLT2 inhibitors and clinical implications
V Vallon - American Journal of Hypertension, 2024 - academic.oup.com
BACKGROUND Inhibitors of the Na+-coupled glucose transporter SGLT2 (SGLT2i) primarily
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
Blood pressure management strategies and podocyte health
M Semenikhina, RO Mathew, M Barakat… - American Journal of …, 2024 - academic.oup.com
Hypertension (HTN) is one of the key global cardiovascular risk factors, which is tightly
linked to kidney health and disease development. Podocytes, glomerular epithelial cells that …
linked to kidney health and disease development. Podocytes, glomerular epithelial cells that …
[HTML][HTML] Sparsentan improves glomerular hemodynamics, cell functions, and tissue repair in a mouse model of FSGS
Dual endothelin-1 (ET-1) and angiotensin II (AngII) receptor antagonism with sparsentan
has strong antiproteinuric actions via multiple potential mechanisms that are more …
has strong antiproteinuric actions via multiple potential mechanisms that are more …
Hold the salt for kidney regeneration
Y Xia, TM Coffman - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
The macula densa (MD) is a distinct cluster of approximately 20 specialized kidney epithelial
cells that constitute a key component of the juxtaglomerular apparatus. Unlike other renal …
cells that constitute a key component of the juxtaglomerular apparatus. Unlike other renal …
Commentary: the perspectives of harnessing the power of scattered tubular-like cells for renal repair
AC Jones, O Palygin, DV Ilatovskaya - Clinical Science, 2024 - portlandpress.com
The commentary discusses the regenerative capacity of the kidneys; recent studies reveal
that renal cells can regenerate when exposed to certain conditions. A major focus is on …
that renal cells can regenerate when exposed to certain conditions. A major focus is on …
See the power in kidney cells with ATP biosensor
J Peti-Peterdi, G Gyarmati - Kidney International, 2024 - Elsevier
Yamamoto et al. developed an exciting technical advance to examine intracellular
adenosine triphosphate levels with single-cell resolution in intact living kidney tissue …
adenosine triphosphate levels with single-cell resolution in intact living kidney tissue …
A contemporary view of the macula densa: kidney remodeling
SJ Shankland, JW Pippin, O Wessely - Kidney International, 2024 - kidney-international.org
A high salt intake has deleterious effects on blood pressure and kidney function in patients
with chronic kidney disease (CKD), compelling a low salt diet as a critical non …
with chronic kidney disease (CKD), compelling a low salt diet as a critical non …
Neuronally differentiated endothelial cell subtype regulates organ blood flow and immune balance
Vascular endothelial cells (ECs) perform key pleiotropic functions to maintain body
homeostasis via the regulation of organ blood flow, vascular permeability, tissue growth and …
homeostasis via the regulation of organ blood flow, vascular permeability, tissue growth and …
Remodelling by macula densa cells
SJ Allison - Nature Reviews Nephrology, 2024 - nature.com
Cells of the macula densa (MD) sense changes in tubular fluid to control functions such as
renal blood flow and renin release. New findings identify a broader role for MD cells in the …
renal blood flow and renin release. New findings identify a broader role for MD cells in the …