The crosstalk between the nerve and stomatognathic systems plays a more important role in
organismal health than previously appreciated with the presence of emerging concept of the …

The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent,
continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and …

Background Mechanotransduction mechanisms whereby periodontal ligament stem cells
(PDLSCs) translate mechanical stress into biochemical signals and thereby trigger …

Regulator of G protein signaling (RGS) proteins are critical negative molecules of G protein-
coupled receptor (GPCR) signaling, which mediates a variety of biological processes in …

Type 2 diabetes (T2D) is on the rise worldwide and is associated with various complications
in the oral cavity. Using an adult-onset diabetes preclinical model, we demonstrated …

Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-
renewal and multilineage differentiation capability with tissue specificity. Among these tissue …

The periodontium is comprised of multiple units of mineralized and nonmineralized tissues
including the cementum on the root surface, the alveolar bone, periodontal ligament (PDL) …

Bone tissue provides structural support for our bodies, with the inner bone marrow (BM)
acting as a hematopoietic organ. Within the BM tissue, two types of stem cells play crucial …

Aim To date, controversies still exist regarding the exact cellular origin and regulatory
mechanisms of periodontium development, which hinders efforts to achieve ideal …

The lineage of periodontal ligament (PDL) stem cells contributes to alveolar bone (AB) and
cementum formation, which are essential for tooth-jawbone attachment. Leptin receptor …