Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

Atherosclerosis is one of the most fatal diseases in the world. The associated thickening of
the arterial wall and its background and consequences make it a very composite disease …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …

Nucleic acid-based therapeutics are currently developed at large scale for prevention and
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …

Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are
the most common cause of death worldwide. The main pathophysiological mechanism for …

Atherosclerosis (AS) is a pathological process involving lipid oxidation, immune system
activation, and endothelial dysfunction. The activated immune system could lead to …

The global dietary supplement market is valued at over USD 100 billion. One popular dietary
supplement, S-adenosylmethionine, is marketed to improve joints, liver health and …

Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque
build-up within arterial vessel walls, acts as the important cause of most cardiovascular …

This review deals with the functional characteristics and biological roles of enzymes
participating in DNA methylation and demethylation as key factors in epigenetic regulation of …