B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

Models of hematopoiesis often depict lymphocyte production as a uniform process in which
a homogenous population of hematopoietic stem cells (HSCs) generates progenitors from …

The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

Despite having several characteristics of naı̈ve B cells, chronic lymphocytic leukemia (CLL)
cells have been shown in some cases to have somatically mutated Ig variable region genes …

The traditional definition of natural antibodies (NAbs) states that these antibodies are
present prior to the body encountering cognate antigen, providing a first line of defense …

The ability of B cells to negatively regulate cellular immune responses and inflammation has
only recently been described. Hallmark papers from a number of distinguished laboratories …

A small population of B cells exists in lymphoid tissues and body cavities of mice that is
distinct in development, phenotype, and function from the majority (B-2) B cell population …

The subclassification of low-grade B-cell lymphomas remains controversial. A particularly
difficult area has been the definition and characterization of the clinical behavior of so-called …

IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a
dimer across mucous membranes. This review discusses the different mechanisms of …

Antibodies that are present in the serum of healthy individuals in the absence of deliberate
immunization with any antigen, are refered to as natural antibodies. A vast majority of natural …