A flavonoid on the brain: quercetin as a potential therapeutic agent in central nervous system disorders

D Wróbel-Biedrawa, K Grabowska, A Galanty… - Life, 2022 - mdpi.com
Quercetin is one of the most common, naturally occurring flavonoids, structurally classified to
the flavonol subfamily. This compound, found in many edible and medicinal plants either as …

Neuroprotective effects of quercetin in pediatric neurological diseases

L Alvarez-Arellano, M Salazar-García, JC Corona - Molecules, 2020 - mdpi.com
Oxidative stress is a crucial event underlying several pediatric neurological diseases, such
as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention …

Challenges and recent advances in medulloblastoma therapy

V Kumar, V Kumar, T McGuire, DW Coulter… - Trends in …, 2017 - cell.com
Medulloblastoma (MB) is the most common childhood brain tumor, which occurs in the
posterior fossa. MB tumors are highly heterogeneous and have diverse genetic make-ups …

Investigating the molecular mechanism of quercetin protecting against podocyte injury to attenuate diabetic nephropathy through network pharmacology …

X Ma, C Hao, M Yu, Z Zhang, J Huang… - Evidence‐Based …, 2022 - Wiley Online Library
Quercetin (QUE), a health supplement, can improve renal function in diabetic nephropathy
(DN) rats by ameliorating podocyte injury. Its clinical trial for renal insufficiency in advanced …

Targeting the radiation-induced ARv7-mediated circNHS/miR-512-5p/XRCC5 signaling with Quercetin increases prostate cancer radiosensitivity

D Chen, FJ Chou, Y Chen, CP Huang, H Tian… - Journal of Experimental …, 2022 - Springer
Background Radiation therapy (RT) with androgen deprivation therapy (ADT) is an effective
therapy to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly …

Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death

V Vendrely, S Amintas, C Noel, I Moranvillier, I Lamrissi… - Cancer letters, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers because it
is highly resistant to every available therapeutic strategy, in particular conventional …

[HTML][HTML] The in vitro radiosensitizer potential of resveratrol on MCF-7 breast cancer cells

IC da Costa Araldi, FPR Bordin, FC Cadoná… - Chemico-biological …, 2018 - Elsevier
Radiation therapy is commonly applied in breast cancer (BC) patients. However,
radioresistance and side effects are limiting factors of this practice. Therefore, studying …

Flavonoids sensitize tumor cells to radiation: molecular mechanisms and relevance to cancer radiotherapy

P Tiwari, KP Mishra - International Journal of Radiation Biology, 2020 - Taylor & Francis
Purpose: Radiobiological research continues to focus on finding newer strategies for
enhanced killing of tumor cells by ionizing radiation. In recent years, chemotherapeutic …

Application of Quercetin and its Novel Formulations in the Treatment of Malignancies of Central Nervous System: An Updated Review of Current Evidence based on …

MS Jamshidi-Mouselou, A Hashemi… - Current Medicinal …, 2024 - benthamdirect.com
Quercetin, a naturally occurring polyphenolic compound found in abundance in vegetables
and fruits, has emerged as a compelling subject of study in cancer treatment. This …

Piperine sensitizes radiation‐resistant cancer cells towards radiation and promotes intrinsic pathway of apoptosis

K Shaheer, HM Somashekarappa… - Journal of Food …, 2020 - Wiley Online Library
Piperine, a bioactive alkaloid, is known to have anticancer activities. Hence, in this study, the
effectiveness of piperine pretreatment as a strategy for radio‐sensitizing colorectal …